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คาลลิสแตติน หรือ เซอร์ปิน เอ4 (อังกฤษ: Kallistatin หรือ SERPINA4) เป็นโปรตีนที่พบในมนุษย์ซึ่งถอดรหัสได้จากยีน SERPINA4 บน ออกฤทธิ์ผ่านการปิดกั้นกิจกรรม amidolytic และยับยั้งการทำงานของเอนไซม์คินิโนไคเนส (kininokinase) ของในเนื้อเยื่อของมนุษย์ ทำให้การก่อตัวของซึ่งเป็นสื่อกลางของการอักเสบถูกปิดกั้น จากการศึกษาในหลอดทดลอง (in vitro) พบว่าในเนื้อเยื่อของตับ กระเพาะอาหาร ตับอ่อน เอออร์ตา ไต อัณฑะ หลอดเลือดแดง หัวใจ ปอด และเซลล์ของท่อหน่วยไตส่วนต้น (Proximal tubule) จะมีการแสดงออกของคาลลิสแตติน มากกว่าเนื้อเยื่ออื่น ๆ
| SERPINA4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SERPINA4, KAL, KLST, KST, PI-4, PI4, kallistatin, serpin family A member 4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | : 147935 : 48412 : SERPINA4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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ดูเพิ่ม
อ้างอิง
- GRCh38: Ensembl release 89: ENSG00000100665 – , May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Chai KX, Chen LM, Chao J, Chao L (ธันวาคม 1993). "Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli". J Biol Chem. 268 (32): 24498–505. PMID 8227002.
- "Entrez Gene: SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4".
แหล่งข้อมูลอื่น
- Chao J, Miao RQ, Chen V, และคณะ (2001). "Novel roles of kallistatin, a specific tissue kallikrein inhibitor, in vascular remodeling". Biol. Chem. 382 (1): 15–21. doi:10.1515/BC.2001.003. PMID 11258665.
- Zhou GX, Chao L, Chao J (1993). "Kallistatin: a novel human tissue kallikrein inhibitor. Purification, characterization, and reactive center sequence". J. Biol. Chem. 267 (36): 25873–80. PMID 1334488.
- Wang MY, Day J, Chao L, Chao J (1990). "Human kallistatin, a new tissue kallikrein-binding protein: purification and characterization". Adv. Exp. Med. Biol. 247B: 1–8. doi:10.1007/978-1-4615-9546-5_1. PMID 2558505.
- Chen LM, Song Q, Chao L, Chao J (1995). "Cellular localization of tissue kallikrein and kallistatin mRNAs in human kidney". Kidney Int. 48 (3): 690–697. doi:10.1038/ki.1995.339. PMID 7474653.
- Chai KX, Ward DC, Chao J, Chao L (1995). "Molecular cloning, sequence analysis, and chromosomal localization of the human protease inhibitor 4 (kallistatin) gene (PI4)". Genomics. 23 (2): 370–378. doi:10.1006/geno.1994.1513. PMID 7835886.
- Chao J, Schmaier A, Chen LM, และคณะ (1996). "Kallistatin, a novel human tissue kallikrein inhibitor: levels in body fluids, blood cells, and tissues in health and disease". J. Lab. Clin. Med. 127 (6): 612–620. doi:10.1016/S0022-2143(96)90152-3. PMID 8648266.
- Wang DZ, Song Q, Chen LM, และคณะ (1996). "Expression and cellular localization of tissue kallikrein-kinin system in human adrenal gland". Am. J. Physiol. 271 (3 Pt 2): F709–16. PMID 8853434.
- Ma JX, King LP, Yang Z, และคณะ (1997). "Kallistatin in human ocular tissues: reduced levels in vitreous fluids from patients with diabetic retinopathy". Curr. Eye Res. 15 (11): 1117–1123. doi:10.3109/02713689608995143. PMID 8950506.
- Wolf WC, Harley RA, Sluce D, และคณะ (1999). "Cellular localization of kallistatin and tissue kallikrein in human pancreas and salivary glands". Histochem. Cell Biol. 110 (5): 477–484. doi:10.1007/s004180050309. PMID 9826127.
- Wolf WC, Harley RA, Sluce D, และคณะ (1999). "Localization and expression of tissue kallikrein and kallistatin in human blood vessels". J. Histochem. Cytochem. 47 (2): 221–8. doi:10.1177/002215549904700210. PMID 9889257.
- Bläckberg M, Berling R, Ohlsson K (2000). "Tissue kallikrein in severe acute pancreatitis in patients treated with high-dose intraperitoneal aprotinin". Pancreas. 19 (4): 325–334. doi:10.1097/00006676-199911000-00002. PMID 10547191.
- Chen VC, Chao L, Chao J (2000). "Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis". Biochim. Biophys. Acta. 1479 (1–2): 237–46. doi:10.1016/S0167-4838(00)00044-3. PMID 10862973.
- Chen VC, Chao L, Chao J (2001). "A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein". J. Biol. Chem. 275 (51): 40371–40377. doi:10.1074/jbc.M005691200. PMID 10991942.
- Chen VC, Chao L, Pimenta DC, และคณะ (2001). "Identification of a major heparin-binding site in kallistatin". J. Biol. Chem. 276 (2): 1276–1284. doi:10.1074/jbc.M005791200. PMID 11016932.
- Pimenta DC, Oliveira A, Juliano MA, Juliano L (2001). "Substrate specificity of human cathepsin D using internally quenched fluorescent peptides derived from reactive site loop of kallistatin". Biochim. Biophys. Acta. 1544 (1–2): 113–22. doi:10.1016/S0167-4838(00)00209-0. PMID 11341921.
- Miao RQ, Agata J, Chao L, Chao J (2002). "Kallistatin is a new inhibitor of angiogenesis and tumor growth". Blood. 100 (9): 3245–3252. doi:10.1182/blood-2002-01-0185. PMID 12384424.
- Strausberg RL, Feingold EA, Grouse LH, และคณะ (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Miao RQ, Chen V, Chao L, Chao J (2003). "Structural elements of kallistatin required for inhibition of angiogenesis". Am. J. Physiol., Cell Physiol. 284 (6): C1604–13. doi:10.1152/ajpgi.00524.2002. PMID 12734113.
- "I04.003". ฐานข้อมูลออนไลน์ สำหรับเปปทิเดส และสารยับยั้งเปปทิเดส. คลังข้อมูลเก่าเก็บจากแหล่งเดิมเมื่อ 23 ธันวาคม 2012.
- SERPINA4 protein, human ใน สำหรับหัวข้อเนื้อหาทางการแพทย์ (MeSH)
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MHLIDYLLLL | LVGLLALSHG | QLHVEHDGES | CSNSSHQQIL | ETGEGSPSLK | ||||
| IAPANADFAF | RFYYLIASET | PGKNIFFSPL | SISAAYAMLS | LGACSHSRSQ | ||||
| ILEGLGFNLT | ELSESDVHRG | FQHLLHTLNL | PGHGLETRVG | SALFLSHNLK | ||||
| FLAKFLNDTM | AVYEAKLFHT | NFYDTVGTIQ | LINDHVKKET | RGKIVDLVSE | ||||
| LKKDVLMVLV | NYIYFKALWE | KPFISSRTTP | KDFYVDENTT | VRVPMMLQDQ | ||||
| EHHWYLHDRY | LPCSVLRMDY | KGDATVFFIL | PNQGKMREIE | EVLTPEMLMR | ||||
| WNNLLRKRNF | YKKLELHLPK | FSISGSYVLD | QILPRLGFTD | LFSKWADLSG | ||||
| ITKQQKLEAS | KSFHKATLDV | DEAGTEAAAA | TSFAIKFFSA | QTNRHILRFN | ||||
| RPFLVVIFST | STQSVLFLGK | VVDPTKP |
A: อะลานีน
C: ซิสตีอีน
D: กรดแอสปาร์ติก
E: กลูตาเมต
F: ฟีนิลอะลานีน
G: ไกลซีน
H:
I:
K: ไลซีน
L: ลิวซีน
M: มีไธโอนีน
N: แอสพาราจีน
P:
Q:
R: อาร์จินีน
S:
T: ทรีโอนีน
V: วาลีน
W: ทริปโตเฟน
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khallisaettin hrux esxrpin ex4 xngkvs Kallistatin hrux SERPINA4 epnoprtinthiphbinmnusysungthxdrhsidcakyin SERPINA4 bn xxkvththiphankarpidknkickrrm amidolytic aelaybyngkarthangankhxngexnismkhinionikhens kininokinase khxnginenuxeyuxkhxngmnusy thaihkarkxtwkhxngsungepnsuxklangkhxngkarxkesbthukpidkn cakkarsuksainhlxdthdlxng in vitro phbwainenuxeyuxkhxngtb kraephaaxahar tbxxn exxxrta it xntha hlxdeluxdaedng hwic pxd aelaesllkhxngthxhnwyitswntn Proximal tubule camikaraesdngxxkkhxngkhallisaettin makkwaenuxeyuxxun SERPINA4IdentifiersSERPINA4 KAL KLST KST PI 4 PI4 kallistatin serpin family A member 4External IDs 147935 48412 SERPINA4Gene location Human Chr 14q32 13Start94 561 442 bpEnd94 569 913 bpRNA expression patternBgeeHuman ortholog Top expressed inright lobe of liver body of pancreas corpus epididymis caput epididymis body of stomach seminal vesicula tail of epididymis tibialis anterior musclen aMore reference expression dataBioGPSMore reference expression dataMolecular functionpeptidase inhibitor activity serine type endopeptidase inhibitor activityCellular componentexkososmchnidphaynxkesll platelet dense granule lumen phaynxkesll extracellular regionBiological processnegative regulation of peptidase activity platelet degranulation negative regulation of endopeptidase activitySources Amigo QuickGOSpeciesHumanMouse5267n aENSG00000100665n aP29622n aRefSeq mRNA NM 006215 NM 001289032 NM 001289033n aRefSeq protein NP 001275961 NP 001275962 NP 006206n aLocation UCSC Chr 14 94 56 94 57 Mbn aPubMed searchn aWikidataView Edit HumanduephimesxrpinxangxingGRCh38 Ensembl release 89 ENSG00000100665 May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Chai KX Chen LM Chao J Chao L thnwakhm 1993 Kallistatin a novel human serine proteinase inhibitor Molecular cloning tissue distribution and expression in Escherichia coli J Biol Chem 268 32 24498 505 PMID 8227002 Entrez Gene SERPINA4 serpin peptidase inhibitor clade A alpha 1 antiproteinase antitrypsin member 4 aehlngkhxmulxunChao J Miao RQ Chen V aelakhna 2001 Novel roles of kallistatin a specific tissue kallikrein inhibitor in vascular remodeling Biol Chem 382 1 15 21 doi 10 1515 BC 2001 003 PMID 11258665 Zhou GX Chao L Chao J 1993 Kallistatin a novel human tissue kallikrein inhibitor Purification characterization and reactive center sequence J Biol Chem 267 36 25873 80 PMID 1334488 Wang MY Day J Chao L Chao J 1990 Human kallistatin a new tissue kallikrein binding protein purification and characterization Adv Exp Med Biol 247B 1 8 doi 10 1007 978 1 4615 9546 5 1 PMID 2558505 Chen LM Song Q Chao L Chao J 1995 Cellular localization of tissue kallikrein and kallistatin mRNAs in human kidney Kidney Int 48 3 690 697 doi 10 1038 ki 1995 339 PMID 7474653 Chai KX Ward DC Chao J Chao L 1995 Molecular cloning sequence analysis and chromosomal localization of the human protease inhibitor 4 kallistatin gene PI4 Genomics 23 2 370 378 doi 10 1006 geno 1994 1513 PMID 7835886 Chao J Schmaier A Chen LM aelakhna 1996 Kallistatin a novel human tissue kallikrein inhibitor levels in body fluids blood cells and tissues in health and disease J Lab Clin Med 127 6 612 620 doi 10 1016 S0022 2143 96 90152 3 PMID 8648266 Wang DZ Song Q Chen LM aelakhna 1996 Expression and cellular localization of tissue kallikrein kinin system in human adrenal gland Am J Physiol 271 3 Pt 2 F709 16 PMID 8853434 Ma JX King LP Yang Z aelakhna 1997 Kallistatin in human ocular tissues reduced levels in vitreous fluids from patients with diabetic retinopathy Curr Eye Res 15 11 1117 1123 doi 10 3109 02713689608995143 PMID 8950506 Wolf WC Harley RA Sluce D aelakhna 1999 Cellular localization of kallistatin and tissue kallikrein in human pancreas and salivary glands Histochem Cell Biol 110 5 477 484 doi 10 1007 s004180050309 PMID 9826127 Wolf WC Harley RA Sluce D aelakhna 1999 Localization and expression of tissue kallikrein and kallistatin in human blood vessels J Histochem Cytochem 47 2 221 8 doi 10 1177 002215549904700210 PMID 9889257 Blackberg M Berling R Ohlsson K 2000 Tissue kallikrein in severe acute pancreatitis in patients treated with high dose intraperitoneal aprotinin Pancreas 19 4 325 334 doi 10 1097 00006676 199911000 00002 PMID 10547191 Chen VC Chao L Chao J 2000 Reactive site specificity of human kallistatin toward tissue kallikrein probed by site directed mutagenesis Biochim Biophys Acta 1479 1 2 237 46 doi 10 1016 S0167 4838 00 00044 3 PMID 10862973 Chen VC Chao L Chao J 2001 A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein J Biol Chem 275 51 40371 40377 doi 10 1074 jbc M005691200 PMID 10991942 Chen VC Chao L Pimenta DC aelakhna 2001 Identification of a major heparin binding site in kallistatin J Biol Chem 276 2 1276 1284 doi 10 1074 jbc M005791200 PMID 11016932 Pimenta DC Oliveira A Juliano MA Juliano L 2001 Substrate specificity of human cathepsin D using internally quenched fluorescent peptides derived from reactive site loop of kallistatin Biochim Biophys Acta 1544 1 2 113 22 doi 10 1016 S0167 4838 00 00209 0 PMID 11341921 Miao RQ Agata J Chao L Chao J 2002 Kallistatin is a new inhibitor of angiogenesis and tumor growth Blood 100 9 3245 3252 doi 10 1182 blood 2002 01 0185 PMID 12384424 Strausberg RL Feingold EA Grouse LH aelakhna 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 16903 doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Miao RQ Chen V Chao L Chao J 2003 Structural elements of kallistatin required for inhibition of angiogenesis Am J Physiol Cell Physiol 284 6 C1604 13 doi 10 1152 ajpgi 00524 2002 PMID 12734113 I04 003 thankhxmulxxniln sahrbeppthieds aelasarybyngeppthieds khlngkhxmulekaekbcakaehlngedimemux 23 thnwakhm 2012 SERPINA4 protein human in sahrbhwkhxenuxhathangkaraephthy MeSH ladbkrdxamion1020304050MHLIDYLLLLLVGLLALSHGQLHVEHDGESCSNSSHQQILETGEGSPSLKIAPANADFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGFNLTELSESDVHRGFQHLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVYEAKLFHTNFYDTVGTIQLINDHVKKETRGKIVDLVSELKKDVLMVLVNYIYFKALWEKPFISSRTTPKDFYVDENTTVRVPMMLQDQEHHWYLHDRYLPCSVLRMDYKGDATVFFILPNQGKMREIEEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQILPRLGFTDLFSKWADLSGITKQQKLEASKSFHKATLDVDEAGTEAAAATSFAIKFFSAQTNRHILRFNRPFLVVIFSTSTQSVLFLGKVVDPTKPA xalanin C sistixin D krdaexspartik E klutaemt F finilxalanin G iklsin H I K ilsin L liwsin M miithoxnin N aexspharacin P Q R xarcinin S T thrioxnin V walin W thripotefn Y ithorsin bthkhwamekiywkhxngkbyinbn niyngepnokhrng khunsamarthchwywikiphiediyidodykarephimetimkhxmul