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เซอร์ปิน บี6 (อังกฤษ: Serpin B6 หรือ SERPINB6) เป็นโปรตีนของมนุษย์ และเป็นโปรตีนสมาชิกลำดับที่ 6 ในเคลดบีของเซอร์ปิน (Serpin family B member 6) ถูกถอดรหัสได้โดยยีน SERPINB6 บน
| SERPINB6 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SERPINB6, CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3, serpin family B member 6 | |||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | : 173321 : 103123 : 20956 : SERPINB6 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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ดูเพิ่ม
อ้างอิง
- GRCh38: Ensembl release 89: ENSG00000124570 – , May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000060147 – , May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Coughlin P, Sun J, Cerruti L, Salem HH, Bird P (Nov 1993). "Cloning and molecular characterization of a human intracellular serine proteinase inhibitor". Proc Natl Acad Sci U S A. 90 (20): 9417–21. doi:10.1073/pnas.90.20.9417. PMC 47579. PMID 8415716.
- Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet. 82 (3–4): 273–7. doi:10.1159/000015118. PMID 9858835.
- "Entrez Gene: SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6".
แหล่งข้อมูลอื่น
- Sun J, Coughlin P, Salem HH, Bird P (1995). "Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris". Biochim. Biophys. Acta. 1252 (1): 28–34. doi:10.1016/0167-4838(95)00108-7. PMID 7548163.
- Coughlin P, Nicholl J, Sun J, และคณะ (1995). "Chromosomal mapping of the human proteinase inhibitor 6 (PI6) gene to 6p25 by fluorescence in situ hybridization". Genomics. 26 (2): 431–3. doi:10.1016/0888-7543(95)80240-M. PMID 7601482.
- Morgenstern KA, Sprecher C, Holth L, และคณะ (1994). "Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases". Biochemistry. 33 (11): 3432–41. doi:10.1021/bi00177a037. PMID 8136380.
- Morgenstern KA, Henzel WJ, Baker JB, และคณะ (1993). "Isolation and characterization of an intracellular serine proteinase inhibitor from a monkey kidney epithelial cell line". J. Biol. Chem. 268 (29): 21560–8. PMID 8408007.
- Coughlin PB, Tetaz T, Salem HH (1993). "Identification and purification of a novel serine proteinase inhibitor". J. Biol. Chem. 268 (13): 9541–7. PMID 8486644.
- Riewald M, Morgenstern KA, Schleef RR (1996). "Identification and characterization of the cytoplasmic antiproteinase (CAP) in human platelets. Evidence for the interaction of CAP with endogenous platelet proteins". J. Biol. Chem. 271 (12): 7160–7. doi:10.1074/jbc.271.12.7160. PMID 8636153.
- Riewald M, Schleef RR (1996). "Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues". J. Biol. Chem. 271 (24): 14526–32. doi:10.1074/jbc.271.24.14526. PMID 8662739.
- Scott FL, Paddle-Ledinek JE, Cerruti L, และคณะ (1999). "Proteinase inhibitor 6 (PI-6) expression in human skin: induction of PI-6 and a PI-6/proteinase complex during keratinocyte differentiation". Exp. Cell Res. 245 (2): 263–71. doi:10.1006/excr.1998.4241. PMID 9851866.
- Mikolajczyk SD, Millar LS, Marker KM, และคณะ (1999). "Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue". Cancer Res. 59 (16): 3927–30. PMID 10463585.
- Saedi MS, Zhu Z, Marker K, และคณะ (2002). "Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells". Int. J. Cancer. 94 (4): 558–63. doi:10.1002/ijc.1501. PMID 11745444.
- Wistow G, Bernstein SL, Wyatt MK, และคณะ (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
- Strausberg RL, Feingold EA, Grouse LH, และคณะ (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Strik MC, Wolbink A, Wouters D, และคณะ (2004). "Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers". Blood. 103 (7): 2710–7. doi:10.1182/blood-2003-08-2981. PMID 14670919.
- Ota T, Suzuki Y, Nishikawa T, และคณะ (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, และคณะ (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Charron Y, Madani R, Nef S, และคณะ (2006). "Expression of serpinb6 serpins in germ and somatic cells of mouse gonads". Mol. Reprod. Dev. 73 (1): 9–19. doi:10.1002/mrd.20385. PMID 16175637.
- Rual JF, Venkatesan K, Hao T, และคณะ (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ฐานข้อมูลออนไลน์ สำหรับเปปทิเดส และสารยับยั้งเปปทิเดส: I04.011[]
- SERPINB6 protein, human ใน สำหรับหัวข้อเนื้อหาทางการแพทย์ (MeSH)
 | บทความเกี่ยวข้องกับยีนบน นี้ยังเป็น คุณสามารถช่วยวิกิพีเดียได้โดยการเพิ่มเติมข้อมูล |
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esxrpin bi6 xngkvs Serpin B6 hrux SERPINB6 epnoprtinkhxngmnusy aelaepnoprtinsmachikladbthi 6 inekhldbikhxngesxrpin Serpin family B member 6 thukthxdrhsidodyyin SERPINB6 bnSERPINB6Available structuresOrtholog search PDBe RCSBList of PDB id codes1M37IdentifiersSERPINB6 CAP DFNB91 MSTP057 PI 6 PI6 PTI SPI3 serpin family B member 6External IDs 173321 103123 20956 SERPINB6Gene location Human Chr 6p25 2Start2 948 159 bpEnd2 972 165 bpGene location Chr Chromosome 13 mouse 13 A3 3 13 14 0 cMStart34 101 901 bpEnd34 186 777 bpRNA expression patternBgeeHuman ortholog Top expressed inright testis left testis right uterine tube body of pancreas apex of heart left ovary right auricle right ovary canal of the cervix right adrenal glandTop expressed instroma of bone marrow ankle joint endothelial cell of lymphatic vessel Ileal epithelium submandibular gland skin of external ear left colonMore reference expression dataBioGPSMore reference expression dataMolecular functionpeptidase inhibitor activity protease binding serine type endopeptidase inhibitor activityCellular componentisothphlasum isotsxl exkososmchnidphaynxkesll niwekhliysesll phaynxkesll eyuxhumesll secretory granule membrane tertiary granule membrane ficolin 1 rich granule membrane extracellular region sarekhluxbesllthimikhxllaecnepnswnprakxb serine protease inhibitor complexBiological processnegative regulation of peptidase activity karidyin cellular response to osmotic stress negative regulation of endopeptidase activity neutrophil degranulationSources Amigo QuickGOSpeciesHumanMouse526920719ENSG00000124570ENSMUSG00000060147P35237Q60854RefSeq mRNA NM 001195291 NM 001271822 NM 001271823 NM 001271824 NM 001271825NM 001297699 NM 001297700 NM 004568 NM 001374515 NM 001374516 NM 001374517NM 001164117 NM 001164118 NM 001243192 NM 009254RefSeq protein NP 001182220 NP 001258751 NP 001258752 NP 001258753 NP 001258754NP 001284628 NP 001284629 NP 004559 NP 001361444 NP 001361445 NP 001361446NP 001157589 NP 001157590 NP 001230121 NP 033280Location UCSC Chr 6 2 95 2 97 MbChr 13 34 1 34 19 MbPubMed searchWikidataView Edit HumanView Edit MouseduephimesxrpinxangxingGRCh38 Ensembl release 89 ENSG00000124570 May 2017 GRCm38 Ensembl release 89 ENSMUSG00000060147 May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Coughlin P Sun J Cerruti L Salem HH Bird P Nov 1993 Cloning and molecular characterization of a human intracellular serine proteinase inhibitor Proc Natl Acad Sci U S A 90 20 9417 21 doi 10 1073 pnas 90 20 9417 PMC 47579 PMID 8415716 Sun J Stephens R Mirza G Kanai H Ragoussis J Bird PI Feb 1999 A serpin gene cluster on human chromosome 6p25 contains PI6 PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes Cytogenet Cell Genet 82 3 4 273 7 doi 10 1159 000015118 PMID 9858835 Entrez Gene SERPINB6 serpin peptidase inhibitor clade B ovalbumin member 6 aehlngkhxmulxunSun J Coughlin P Salem HH Bird P 1995 Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris Biochim Biophys Acta 1252 1 28 34 doi 10 1016 0167 4838 95 00108 7 PMID 7548163 Coughlin P Nicholl J Sun J aelakhna 1995 Chromosomal mapping of the human proteinase inhibitor 6 PI6 gene to 6p25 by fluorescence in situ hybridization Genomics 26 2 431 3 doi 10 1016 0888 7543 95 80240 M PMID 7601482 Morgenstern KA Sprecher C Holth L aelakhna 1994 Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor mechanism of action with trypsin and factor Xa as model proteinases Biochemistry 33 11 3432 41 doi 10 1021 bi00177a037 PMID 8136380 Morgenstern KA Henzel WJ Baker JB aelakhna 1993 Isolation and characterization of an intracellular serine proteinase inhibitor from a monkey kidney epithelial cell line J Biol Chem 268 29 21560 8 PMID 8408007 Coughlin PB Tetaz T Salem HH 1993 Identification and purification of a novel serine proteinase inhibitor J Biol Chem 268 13 9541 7 PMID 8486644 Riewald M Morgenstern KA Schleef RR 1996 Identification and characterization of the cytoplasmic antiproteinase CAP in human platelets Evidence for the interaction of CAP with endogenous platelet proteins J Biol Chem 271 12 7160 7 doi 10 1074 jbc 271 12 7160 PMID 8636153 Riewald M Schleef RR 1996 Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin like proteases utilizing distinct reactive site residues J Biol Chem 271 24 14526 32 doi 10 1074 jbc 271 24 14526 PMID 8662739 Scott FL Paddle Ledinek JE Cerruti L aelakhna 1999 Proteinase inhibitor 6 PI 6 expression in human skin induction of PI 6 and a PI 6 proteinase complex during keratinocyte differentiation Exp Cell Res 245 2 263 71 doi 10 1006 excr 1998 4241 PMID 9851866 Mikolajczyk SD Millar LS Marker KM aelakhna 1999 Identification of a novel complex between human kallikrein 2 and protease inhibitor 6 in prostate cancer tissue Cancer Res 59 16 3927 30 PMID 10463585 Saedi MS Zhu Z Marker K aelakhna 2002 Human kallikrein 2 hK2 but not prostate specific antigen PSA rapidly complexes with protease inhibitor 6 PI 6 released from prostate carcinoma cells Int J Cancer 94 4 558 63 doi 10 1002 ijc 1501 PMID 11745444 Wistow G Bernstein SL Wyatt MK aelakhna 2002 Expressed sequence tag analysis of adult human lens for the NEIBank Project over 2000 non redundant transcripts novel genes and splice variants Mol Vis 8 171 84 PMID 12107413 Strausberg RL Feingold EA Grouse LH aelakhna 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Strik MC Wolbink A Wouters D aelakhna 2004 Intracellular serpin SERPINB6 PI6 is abundantly expressed by human mast cells and forms complexes with beta tryptase monomers Blood 103 7 2710 7 doi 10 1182 blood 2003 08 2981 PMID 14670919 Ota T Suzuki Y Nishikawa T aelakhna 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Gerhard DS Wagner L Feingold EA aelakhna 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Charron Y Madani R Nef S aelakhna 2006 Expression of serpinb6 serpins in germ and somatic cells of mouse gonads Mol Reprod Dev 73 1 9 19 doi 10 1002 mrd 20385 PMID 16175637 Rual JF Venkatesan K Hao T aelakhna 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 doi 10 1038 nature04209 PMID 16189514 thankhxmulxxniln sahrbeppthieds aelasarybyngeppthieds I04 011 lingkesiy SERPINB6 protein human in sahrbhwkhxenuxhathangkaraephthy MeSH bthkhwamekiywkhxngkbyinbn niyngepnokhrng khunsamarthchwywikiphiediyidodykarephimetimkhxmul