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เซอร์ปิน บี3 (อังกฤษ: Serpin B3 หรือ SERPINB3, Squamous cell carcinoma antigen-1; SCCA1) เป็นโปรตีนของมนุษย์ และเป็นโปรตีนสมาชิกลำดับที่ 3 ในเคลดบีของเซอร์ปิน (Serpin family B member 3) ถูกถอดรหัสได้จากยีน SERPINB3 บน
| SERPINB3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SERPINB3, HsT1196, SCC, SCCA-1, SCCA-PD, SCCA1, T4-A, SSCA1, serpin family B member 3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | : 600517 : 2683295 : 130559 : SERPINB3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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ดูเพิ่ม
อ้างอิง
- GRCh38: Ensembl release 89: ENSG00000057149 – , May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000058017 – , May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA (May 1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene". Proc Natl Acad Sci U S A. 92 (8): 3147–51. doi:10.1073/pnas.92.8.3147. PMC 42122. PMID 7724531.
- "Entrez Gene: SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3".
แหล่งข้อมูลอื่น
- Suminami Y, Kishi F, Sekiguchi K, Kato H (1992). "Squamous cell carcinoma antigen is a new member of the serine protease inhibitors". Biochem. Biophys. Res. Commun. 181 (1): 51–8. doi:10.1016/S0006-291X(05)81380-4. PMID 1958219.
- Mino-Miyagawa N, Kimura Y, Hamamoto K (1990). "Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus". Cancer. 66 (7): 1505–12. doi:10.1002/1097-0142(19901001)66:7<1505::AID-CNCR2820660712>3.0.CO;2-V. PMID 2208001.
- Mino N, Iio A, Hamamoto K (1988). "Availability of tumor-antigen 4 as a marker of squamous cell carcinoma of the lung and other organs". Cancer. 62 (4): 730–4. doi:10.1002/1097-0142(19880815)62:4<730::AID-CNCR2820620415>3.0.CO;2-W. PMID 2840187.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, และคณะ (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Schick C, Pemberton PA, Shi GP, และคณะ (1998). "Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis". Biochemistry. 37 (15): 5258–66. doi:10.1021/bi972521d. PMID 9548757.
- Cataltepe S, Gornstein ER, Schick C, และคณะ (2000). "Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas". J. Histochem. Cytochem. 48 (1): 113–22. doi:10.1177/002215540004800112. PMID 10653592.
- Uemura Y, Pak SC, Luke C, และคณะ (2000). "Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells". Int. J. Cancer. 89 (4): 368–77. doi:10.1002/1097-0215(20000720)89:4<368::AID-IJC9>3.0.CO;2-6. PMID 10956412.
- Hamada K, Shinomiya H, Asano Y, และคณะ (2001). "Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter". Biochim. Biophys. Acta. 1518 (1–2): 124–31. doi:10.1016/s0167-4781(01)00174-9. PMID 11267667.
- Strausberg RL, Feingold EA, Grouse LH, และคณะ (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Shimada H, Nabeya Y, Okazumi S, และคณะ (2003). "Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma". Surgery. 133 (5): 486–94. doi:10.1067/msy.2003.139. PMID 12773976.
- Micke O, Bruns F, Schäfer U, และคณะ (2003). "The clinical value of squamous cell carcinoma antigen in patients irradiated for locally advanced cancer of the head and neck". Anticancer Res. 23 (2A): 907–11. PMID 12820321.
- Nawata S, Nakamura K, Hirakawa H, และคณะ (2004). "Electrophoretic analysis of the cleaved form of serpin, squamous cell carcinoma antigen-1 in normal and malignant squamous epithelial tissues". Electrophoresis. 24 (14): 2277–82. doi:10.1002/elps.200305501. PMID 12874860. S2CID 41852542.
- Masumoto K, Sakata Y, Arima K, และคณะ (2003). "Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1". J. Biol. Chem. 278 (46): 45296–304. doi:10.1074/jbc.M307741200. PMID 12949073.
- Moore PL, Ong S, Harrison TJ (2004). "Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system". J. Biol. Chem. 278 (47): 46709–17. doi:10.1074/jbc.M302842200. PMID 12975381.
- Onishi A, Nakashiro K, Mihara M, และคณะ (2004). "Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer". Oncol. Rep. 11 (1): 33–9. doi:10.3892/or.11.1.33. PMID 14654899.
- Hirakawa H, Nawata S, Sueoka K, และคณะ (2004). "Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line". Oncol. Rep. 11 (2): 415–9. doi:10.3892/or.11.2.415. PMID 14719077.
- Pontisso P, Calabrese F, Benvegnù L, และคณะ (2004). "Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma". Br. J. Cancer. 90 (4): 833–7. doi:10.1038/sj.bjc.6601543. PMC 2410161. PMID 14970861.
- Ruvoletto MG, Tono N, Carollo D, และคณะ (2004). "Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus". J. Gen. Virol. 85 (Pt 3): 621–4. doi:10.1099/vir.0.19130-0. PMID 14993646.
- Turato, C; Ruvoletto, MG; Biasiolo, A; และคณะ (Mar 2009). "Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease". Dig Liver Dis. 41 (3): 212–6. doi:10.1016/j.dld.2008.06.001. PMID 18657489.
- * ฐานข้อมูลออนไลน์ สำหรับเปปทิเดส และสารยับยั้งเปปทิเดส: I04.008[]
- SERPINB3 protein, human ใน สำหรับหัวข้อเนื้อหาทางการแพทย์ (MeSH)
 | บทความเกี่ยวข้องกับยีนบน นี้ยังเป็น คุณสามารถช่วยวิกิพีเดียได้โดยการเพิ่มเติมข้อมูล |
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esxrpin bi3 xngkvs Serpin B3 hrux SERPINB3 Squamous cell carcinoma antigen 1 SCCA1 epnoprtinkhxngmnusy aelaepnoprtinsmachikladbthi 3 inekhldbikhxngesxrpin Serpin family B member 3 thukthxdrhsidcakyin SERPINB3 bnSERPINB3Available structuresOrtholog search PDBe RCSBList of PDB id codes2ZV6 4ZK0 4ZK3IdentifiersSERPINB3 HsT1196 SCC SCCA 1 SCCA PD SCCA1 T4 A SSCA1 serpin family B member 3External IDs 600517 2683295 130559 SERPINB3Gene location Human Chr 18q21 33Start63 655 197 bpEnd63 661 893 bpGene location Chr Chromosome 1 mouse 1 E2 1 1Start107 005 897 bpEnd107 011 236 bpRNA expression patternBgeeHuman ortholog Top expressed inolfactory zone of nasal mucosa nasal epithelium mucosa of paranasal sinus epithelium of bronchus bronchial epithelial cell gums gingival epithelium mucosa of pharynxn aMore reference expression dataBioGPSMore reference expression dataMolecular functionvirus receptor activity protease binding cysteine type endopeptidase inhibitor activity peptidase inhibitor activity serine type endopeptidase inhibitor activityCellular componentniwekhliysesll ewsiekhil cytoplasmic vesicle exkososmchnidphaynxkesll isothphlasum extracellular region phaynxkesll azurophil granule lumenBiological processparacrine signaling positive regulation of cell population proliferation autocrine signaling negative regulation of catalytic activity negative regulation of JUN kinase activity positive regulation of endopeptidase activity positive regulation of epithelial to mesenchymal transition negative regulation of proteolysis negative regulation of endopeptidase activity positive regulation of cell migration viral entry into host cell negative regulation of peptidase activity neutrophil degranulationSources Amigo QuickGOSpeciesHumanMouse6317394252ENSG00000057149ENSMUSG00000058017P29508Q6UKZ0RefSeq mRNA NM 006919NM 201376RefSeq protein NP 008850NP 958764Location UCSC Chr 18 63 66 63 66 MbChr 1 107 01 107 01 MbPubMed searchWikidataView Edit HumanView Edit MouseduephimesxrpinxangxingGRCh38 Ensembl release 89 ENSG00000057149 May 2017 GRCm38 Ensembl release 89 ENSMUSG00000058017 May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Schneider SS Schick C Fish KE Miller E Pena JC Treter SD Hui SM Silverman GA May 1995 A serine proteinase inhibitor locus at 18q21 3 contains a tandem duplication of the human squamous cell carcinoma antigen gene Proc Natl Acad Sci U S A 92 8 3147 51 doi 10 1073 pnas 92 8 3147 PMC 42122 PMID 7724531 Entrez Gene SERPINB3 serpin peptidase inhibitor clade B ovalbumin member 3 aehlngkhxmulxunSuminami Y Kishi F Sekiguchi K Kato H 1992 Squamous cell carcinoma antigen is a new member of the serine protease inhibitors Biochem Biophys Res Commun 181 1 51 8 doi 10 1016 S0006 291X 05 81380 4 PMID 1958219 Mino Miyagawa N Kimura Y Hamamoto K 1990 Tumor antigen 4 Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus Cancer 66 7 1505 12 doi 10 1002 1097 0142 19901001 66 7 lt 1505 AID CNCR2820660712 gt 3 0 CO 2 V PMID 2208001 Mino N Iio A Hamamoto K 1988 Availability of tumor antigen 4 as a marker of squamous cell carcinoma of the lung and other organs Cancer 62 4 730 4 doi 10 1002 1097 0142 19880815 62 4 lt 730 AID CNCR2820620415 gt 3 0 CO 2 W PMID 2840187 Maruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K aelakhna 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Schick C Pemberton PA Shi GP aelakhna 1998 Cross class inhibition of the cysteine proteinases cathepsins K L and S by the serpin squamous cell carcinoma antigen 1 a kinetic analysis Biochemistry 37 15 5258 66 doi 10 1021 bi972521d PMID 9548757 Cataltepe S Gornstein ER Schick C aelakhna 2000 Co expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas J Histochem Cytochem 48 1 113 22 doi 10 1177 002215540004800112 PMID 10653592 Uemura Y Pak SC Luke C aelakhna 2000 Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells Int J Cancer 89 4 368 77 doi 10 1002 1097 0215 20000720 89 4 lt 368 AID IJC9 gt 3 0 CO 2 6 PMID 10956412 Hamada K Shinomiya H Asano Y aelakhna 2001 Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter Biochim Biophys Acta 1518 1 2 124 31 doi 10 1016 s0167 4781 01 00174 9 PMID 11267667 Strausberg RL Feingold EA Grouse LH aelakhna 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Shimada H Nabeya Y Okazumi S aelakhna 2003 Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma Surgery 133 5 486 94 doi 10 1067 msy 2003 139 PMID 12773976 Micke O Bruns F Schafer U aelakhna 2003 The clinical value of squamous cell carcinoma antigen in patients irradiated for locally advanced cancer of the head and neck Anticancer Res 23 2A 907 11 PMID 12820321 Nawata S Nakamura K Hirakawa H aelakhna 2004 Electrophoretic analysis of the cleaved form of serpin squamous cell carcinoma antigen 1 in normal and malignant squamous epithelial tissues Electrophoresis 24 14 2277 82 doi 10 1002 elps 200305501 PMID 12874860 S2CID 41852542 Masumoto K Sakata Y Arima K aelakhna 2003 Inhibitory mechanism of a cross class serpin the squamous cell carcinoma antigen 1 J Biol Chem 278 46 45296 304 doi 10 1074 jbc M307741200 PMID 12949073 Moore PL Ong S Harrison TJ 2004 Squamous cell carcinoma antigen 1 mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system J Biol Chem 278 47 46709 17 doi 10 1074 jbc M302842200 PMID 12975381 Onishi A Nakashiro K Mihara M aelakhna 2004 Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer Oncol Rep 11 1 33 9 doi 10 3892 or 11 1 33 PMID 14654899 Hirakawa H Nawata S Sueoka K aelakhna 2004 Regulation of squamous cell carcinoma antigen production by E cadherin mediated cell cell adhesion in squamous cell carcinoma cell line Oncol Rep 11 2 415 9 doi 10 3892 or 11 2 415 PMID 14719077 Pontisso P Calabrese F Benvegnu L aelakhna 2004 Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma Br J Cancer 90 4 833 7 doi 10 1038 sj bjc 6601543 PMC 2410161 PMID 14970861 Ruvoletto MG Tono N Carollo D aelakhna 2004 Surface expression of squamous cell carcinoma antigen SCCA can be increased by the preS1 21 47 sequence of hepatitis B virus J Gen Virol 85 Pt 3 621 4 doi 10 1099 vir 0 19130 0 PMID 14993646 Turato C Ruvoletto MG Biasiolo A aelakhna Mar 2009 Squamous cell carcinoma antigen 1 SERPINB3 polymorphism in chronic liver disease Dig Liver Dis 41 3 212 6 doi 10 1016 j dld 2008 06 001 PMID 18657489 thankhxmulxxniln sahrbeppthieds aelasarybyngeppthieds I04 008 lingkesiy SERPINB3 protein human in sahrbhwkhxenuxhathangkaraephthy MeSH bthkhwamekiywkhxngkbyinbn niyngepnokhrng khunsamarthchwywikiphiediyidodykarephimetimkhxmul