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เซอร์ปิน บี9 (อังกฤษ: Serpin B9 หรือ SERPINB9) เป็นโปรตีนในมนุษย์ที่ถูกถอดรหัสโดยยีน SERPINB9 บน เป็นโปรตีนสมาชิกของเซอร์ปิน (serine proteinase inhibitors;serpins) ที่ทำหน้าที่เข้าจับและยับยั้งการทำงานของเอนไซม์ (serine proteinase) ซึ่งส่งผลต่อกระบวนการต่างๆภายในเซลล์หลายอย่าง อาทิ การจับลิ่มของเลือด, , การสร้างเมทริกซ์, การเกิดอะพอพโทซิสของเซลล์
| SERPINB9 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SERPINB9, CAP-3, CAP3, PI-9, PI9, serpin family B member 9 | |||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | : 601799 : 106603 : 37888 : SERPINB9 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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ดูเพิ่ม
อ้างอิง
- GRCh38: Ensembl release 89: ENSG00000170542 – , May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000045827 – , May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Sprecher CA, Morgenstern KA, Mathewes S, Dahlen JR, Schrader SK, Foster DC, Kisiel W (Jan 1996). "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors". J Biol Chem. 270 (50): 29854–61. doi:10.1074/jbc.270.50.29854. PMID 8530382.
- Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet. 82 (3–4): 273–7. doi:10.1159/000015118. PMID 9858835.
- "Entrez Gene: SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9".
แหล่งข้อมูลอื่น
- Sun J, Bird CH, Sutton V, และคณะ (1996). "A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes". J. Biol. Chem. 271 (44): 27802–9. doi:10.1074/jbc.271.44.27802. PMID 8910377.
- Annand RR, Dahlen JR, Sprecher CA, และคณะ (1999). "Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9". Biochem. J. 342 Pt 3 (3): 655–65. doi:10.1042/0264-6021:3420655. PMC 1220507. PMID 10477277.
- Kanamori H, Krieg S, Mao C, และคณะ (2000). "Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells". J. Biol. Chem. 275 (8): 5867–73. doi:10.1074/jbc.275.8.5867. PMID 10681578.
- Bladergroen BA, Strik MC, Bovenschen N, และคณะ (2001). "The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites". J. Immunol. 166 (5): 3218–25. doi:10.4049/jimmunol.166.5.3218. PMID 11207275.
- Buzza MS, Hirst CE, Bird CH, และคณะ (2001). "The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses". Cell. Immunol. 210 (1): 21–9. doi:10.1006/cimm.2001.1806. PMID 11485349.
- Hirst CE, Buzza MS, Sutton VR, และคณะ (2002). "Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction". Mol. Hum. Reprod. 7 (12): 1133–42. doi:10.1093/molehr/7.12.1133. PMID 11719590.
- Tanaka K, Harashima N, Niiya F, และคณะ (2002). "Serine proteinase inhibitor 9 can be recognized by cytotoxic T lymphocytes of epithelial cancer patients". Jpn. J. Cancer Res. 93 (2): 198–208. doi:10.1111/j.1349-7006.2002.tb01259.x. PMC 5926951. PMID 11856484.
- ten Berge RL, Meijer CJ, Dukers DF, และคณะ (2002). "Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma". Blood. 99 (12): 4540–6. doi:10.1182/blood.V99.12.4540. PMID 12036886.
- Strausberg RL, Feingold EA, Grouse LH, และคณะ (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hirst CE, Buzza MS, Bird CH, และคณะ (2003). "The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency". J. Immunol. 170 (2): 805–15. doi:10.4049/jimmunol.170.2.805. PMID 12517944.
- Rowshani AT, Florquin S, Bemelman F, และคณะ (2005). "Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection". Kidney Int. 66 (4): 1417–22. doi:10.1111/j.1523-1755.2004.00903.x. PMID 15458434.
- Gerhard DS, Wagner L, Feingold EA, และคณะ (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mahrus S, Kisiel W, Craik CS (2005). "Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B". J. Biol. Chem. 279 (52): 54275–82. doi:10.1074/jbc.M411482200. PMID 15494398.
- Classen CF, Ushmorov A, Bird P, Debatin KM (2006). "The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias". Haematologica. 89 (11): 1314–21. PMID 15531453.
- Bruneel A, Labas V, Mailloux A, และคณะ (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
- van Houdt IS, Oudejans JJ, van den Eertwegh AJ, และคณะ (2005). "Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma". Clin. Cancer Res. 11 (17): 6400–7. doi:10.1158/1078-0432.CCR-05-0306. PMID 16144945.
- Stelzl U, Worm U, Lalowski M, และคณะ (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. :11858/00-001M-0000-0010-8592-0. PMID 16169070.
- Rual JF, Venkatesan K, Hao T, และคณะ (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ฐานข้อมูลออนไลน์ สำหรับเปปทิเดส และสารยับยั้งเปปทิเดส: I04.014[]
- SERPINB9 protein, human ใน สำหรับหัวข้อเนื้อหาทางการแพทย์ (MeSH)
บทความนี้รวบรวมข้อมูลจาก ซึ่งจัดเป็นสาธารณสมบัติ
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esxrpin bi9 xngkvs Serpin B9 hrux SERPINB9 epnoprtininmnusythithukthxdrhsodyyin SERPINB9 bn epnoprtinsmachikkhxngesxrpin serine proteinase inhibitors serpins thithahnathiekhacbaelaybyngkarthangankhxngexnism serine proteinase sungsngphltxkrabwnkartangphayinesllhlayxyang xathi karcblimkhxngeluxd karsrangemthriks karekidxaphxphothsiskhxngesllSERPINB9IdentifiersSERPINB9 CAP 3 CAP3 PI 9 PI9 serpin family B member 9External IDs 601799 106603 37888 SERPINB9Gene location Human Chr 6p25 2Start2 887 270 bpEnd2 903 309 bpGene location Chr Chromosome 13 mouse 13 A3 2 A3 3 13 13 79 cMStart33 187 233 bpEnd33 201 940 bpRNA expression patternBgeeHuman ortholog Top expressed inepithelium of nasopharynx mononuclear cell germinal epithelium tibial nerveTop expressed inright lung lobe gastrula left lung mesenteric lymph nodes left lung lobe lumbar spinal ganglion Epithelium of choroid plexus carotid bodyMore reference expression dataBioGPSMore reference expression dataMolecular functionpeptidase inhibitor activity cysteine type endopeptidase inhibitor activity involved in apoptotic process protease binding karcbkboprtin serine type endopeptidase inhibitor activityCellular componentisotsxl eyuxhum phayinesll exkososmchnidphaynxkesll niwekhliysesll isothphlasum phaynxkesll niwkhlioxphlassum kxlcikhxmephlks sarekhluxbesllthimikhxllaecnepnswnprakxbBiological processnegative regulation of peptidase activity mast cell mediated immunity karkhwbkhumechinglbtxxaphxphothsis protection from natural killer cell mediated cytotoxicity cellular response to estrogen stimulus positive regulation of gene expression negative regulation by symbiont of host apoptotic process kartxbsnxngkhxngphumikhumkn negative regulation of endopeptidase activity xaphxphothsis karkhwbkhumechinglbtxkarthangankhxngexnismeppthiedsphayinesll chnidsistin inkrabwnkarxaphxphothsiSources Amigo QuickGOSpeciesHumanMouse527220723ENSG00000170542ENSMUSG00000045827P50453O08797RefSeq mRNA NM 004155NM 009256RefSeq protein NP 004146 NP 004146 1NP 033282Location UCSC Chr 6 2 89 2 9 MbChr 13 33 19 33 2 MbPubMed searchWikidataView Edit HumanView Edit MouseduephimesxrpinxangxingGRCh38 Ensembl release 89 ENSG00000170542 May 2017 GRCm38 Ensembl release 89 ENSMUSG00000045827 May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Sprecher CA Morgenstern KA Mathewes S Dahlen JR Schrader SK Foster DC Kisiel W Jan 1996 Molecular cloning expression and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors J Biol Chem 270 50 29854 61 doi 10 1074 jbc 270 50 29854 PMID 8530382 Sun J Stephens R Mirza G Kanai H Ragoussis J Bird PI Feb 1999 A serpin gene cluster on human chromosome 6p25 contains PI6 PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes Cytogenet Cell Genet 82 3 4 273 7 doi 10 1159 000015118 PMID 9858835 Entrez Gene SERPINB9 serpin peptidase inhibitor clade B ovalbumin member 9 aehlngkhxmulxunSun J Bird CH Sutton V aelakhna 1996 A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes J Biol Chem 271 44 27802 9 doi 10 1074 jbc 271 44 27802 PMID 8910377 Annand RR Dahlen JR Sprecher CA aelakhna 1999 Caspase 1 interleukin 1beta converting enzyme is inhibited by the human serpin analogue proteinase inhibitor 9 Biochem J 342 Pt 3 3 655 65 doi 10 1042 0264 6021 3420655 PMC 1220507 PMID 10477277 Kanamori H Krieg S Mao C aelakhna 2000 Proteinase inhibitor 9 an inhibitor of granzyme B mediated apoptosis is a primary estrogen inducible gene in human liver cells J Biol Chem 275 8 5867 73 doi 10 1074 jbc 275 8 5867 PMID 10681578 Bladergroen BA Strik MC Bovenschen N aelakhna 2001 The granzyme B inhibitor protease inhibitor 9 is mainly expressed by dendritic cells and at immune privileged sites J Immunol 166 5 3218 25 doi 10 4049 jimmunol 166 5 3218 PMID 11207275 Buzza MS Hirst CE Bird CH aelakhna 2001 The granzyme B inhibitor PI 9 is present in endothelial and mesothelial cells suggesting that it protects bystander cells during immune responses Cell Immunol 210 1 21 9 doi 10 1006 cimm 2001 1806 PMID 11485349 Hirst CE Buzza MS Sutton VR aelakhna 2002 Perforin independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B mediated proteolysis in reproduction Mol Hum Reprod 7 12 1133 42 doi 10 1093 molehr 7 12 1133 PMID 11719590 Tanaka K Harashima N Niiya F aelakhna 2002 Serine proteinase inhibitor 9 can be recognized by cytotoxic T lymphocytes of epithelial cancer patients Jpn J Cancer Res 93 2 198 208 doi 10 1111 j 1349 7006 2002 tb01259 x PMC 5926951 PMID 11856484 ten Berge RL Meijer CJ Dukers DF aelakhna 2002 Expression levels of apoptosis related proteins predict clinical outcome in anaplastic large cell lymphoma Blood 99 12 4540 6 doi 10 1182 blood V99 12 4540 PMID 12036886 Strausberg RL Feingold EA Grouse LH aelakhna 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Hirst CE Buzza MS Bird CH aelakhna 2003 The intracellular granzyme B inhibitor proteinase inhibitor 9 is up regulated during accessory cell maturation and effector cell degranulation and its overexpression enhances CTL potency J Immunol 170 2 805 15 doi 10 4049 jimmunol 170 2 805 PMID 12517944 Rowshani AT Florquin S Bemelman F aelakhna 2005 Hyperexpression of the granzyme B inhibitor PI 9 in human renal allografts a potential mechanism for stable renal function in patients with subclinical rejection Kidney Int 66 4 1417 22 doi 10 1111 j 1523 1755 2004 00903 x PMID 15458434 Gerhard DS Wagner L Feingold EA aelakhna 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Mahrus S Kisiel W Craik CS 2005 Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9 an endogenous inhibitor of granzyme B J Biol Chem 279 52 54275 82 doi 10 1074 jbc M411482200 PMID 15494398 Classen CF Ushmorov A Bird P Debatin KM 2006 The granzyme B inhibitor PI 9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias Haematologica 89 11 1314 21 PMID 15531453 Bruneel A Labas V Mailloux A aelakhna 2006 Proteomics of human umbilical vein endothelial cells applied to etoposide induced apoptosis Proteomics 5 15 3876 84 doi 10 1002 pmic 200401239 PMID 16130169 van Houdt IS Oudejans JJ van den Eertwegh AJ aelakhna 2005 Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma Clin Cancer Res 11 17 6400 7 doi 10 1158 1078 0432 CCR 05 0306 PMID 16144945 Stelzl U Worm U Lalowski M aelakhna 2005 A human protein protein interaction network a resource for annotating the proteome Cell 122 6 957 68 doi 10 1016 j cell 2005 08 029 11858 00 001M 0000 0010 8592 0 PMID 16169070 Rual JF Venkatesan K Hao T aelakhna 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 doi 10 1038 nature04209 PMID 16189514 thankhxmulxxniln sahrbeppthieds aelasarybyngeppthieds I04 014 lingkesiy SERPINB9 protein human in sahrbhwkhxenuxhathangkaraephthy MeSH bthkhwamnirwbrwmkhxmulcak sungcdepnsatharnsmbti bthkhwamekiywkhxngkbyinbn niyngepnokhrng khunsamarthchwywikiphiediyidodykarephimetimkhxmul