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เซอร์ปิน บี7 (อังกฤษ: Serpin B7 หรือ SERPINB7) เป็นโปรตีนของมนุษย์ และเป็นโปรตีนสมาชิกลำดับที่ 7 ในเคลดบีของเซอร์ปิน (Serpin family B member 7) ถูกถอดรหัสได้โดยยีน SERPINB7 บน
| SERPINB7 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SERPINB7, MEGSIN, PPKN, TP55, serpin family B member 7 | |||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | : 603357 : 2151053 : 68363 : SERPINB7 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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ดูเพิ่ม
อ้างอิง
- GRCh38: Ensembl release 89: ENSG00000166396 – , May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000067001 – , May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7".
แหล่งข้อมูลอื่น
- Tsujimoto M, Tsuruoka N, Ishida N, และคณะ (1997). "Purification, cDNA cloning, and characterization of a new serpin with megakaryocyte maturation activity". J. Biol. Chem. 272 (24): 15373–80. doi:10.1074/jbc.272.24.15373. PMID 9182567.
- Miyata T, Nangaku M, Suzuki D, และคณะ (1998). "A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy". J. Clin. Invest. 102 (4): 828–36. doi:10.1172/JCI2450. PMC 508946. PMID 9710452.
- Inagi R, Miyata T, Suzuki D, และคณะ (2001). "Specific tissue distribution of megsin, a novel serpin, in the glomerulus and its up-regulation in IgA nephropathy". Biochem. Biophys. Res. Commun. 286 (5): 1098–106. doi:10.1006/bbrc.2001.5509. PMID 11527413.
- Inagi R, Miyata T, Imasawa T, และคณะ (2003). "Mesangial cell-predominant gene, megsin". Nephrol. Dial. Transplant. 17 Suppl 9 (90009): 32–3. doi:10.1093/ndt/17.suppl_9.32. PMID 12386281.
- Inagi R, Miyata T, Nangaku M, และคณะ (2003). "Transcriptional regulation of a mesangium-predominant gene, megsin" (PDF). J. Am. Soc. Nephrol. 13 (11): 2715–22. doi:10.1097/01.ASN.0000033507.32175.FA. PMID 12397041.
- Strausberg RL, Feingold EA, Grouse LH, และคณะ (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Li YJ, Du Y, Li CX, และคณะ (2004). "Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene". J. Am. Soc. Nephrol. 15 (7): 1739–43. doi:10.1097/01.ASN.0000130858.00688.46. PMID 15213261.
- Suzuki Y, Yamashita R, Shirota M, และคณะ (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, และคณะ (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Inagi R, Nangaku M, Usuda N, และคณะ (2005). "Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsin". J. Am. Soc. Nephrol. 16 (5): 1339–49. doi:10.1681/ASN.2004070600. PMID 15788472.
- Xia Y, Li Y, Du Y, และคณะ (2006). "Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy". Nephrol. Dial. Transplant. 21 (6): 1570–4. doi:10.1093/ndt/gfk096. PMID 16431886.
- Xia YF, Huang S, Li X, และคณะ (2006). "A family-based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese population". Clin. Nephrol. 65 (3): 153–9. doi:10.5414/cnp65153. PMID 16550745.
- ฐานข้อมูลออนไลน์ สำหรับเปปทิเดส และสารยับยั้งเปปทิเดส: I04.012[]
- SERPINB7 protein, human ใน สำหรับหัวข้อเนื้อหาทางการแพทย์ (MeSH)
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esxrpin bi7 xngkvs Serpin B7 hrux SERPINB7 epnoprtinkhxngmnusy aelaepnoprtinsmachikladbthi 7 inekhldbikhxngesxrpin Serpin family B member 7 thukthxdrhsidodyyin SERPINB7 bnSERPINB7IdentifiersSERPINB7 MEGSIN PPKN TP55 serpin family B member 7External IDs 603357 2151053 68363 SERPINB7Gene location Human Chr 18q21 33Start63 752 935 bpEnd63 805 376 bpGene location Chr Chromosome 1 mouse 1 1 E2 1Start107 327 385 bpEnd107 380 419 bpRNA expression patternBgeeHuman ortholog Top expressed inskin of arm skin of leg skin of abdomen skin of thigh skin of hip epithelium of nasopharynx bronchial epithelial cellTop expressed inskin of external ear skin of abdomen skin of back condyle fossa cervixMore reference expression dataBioGPSMore reference expression dataMolecular functionpeptidase inhibitor activity serine type endopeptidase inhibitor activityCellular componentisothphlasum phaynxkesllBiological processpositive regulation of collagen biosynthetic process positive regulation of transforming growth factor beta1 production negative regulation of peptidase activity positive regulation of glomerular mesangial cell proliferation positive regulation of platelet derived growth factor production negative regulation of endopeptidase activitySources Amigo QuickGOSpeciesHumanMouse8710116872ENSG00000166396ENSMUSG00000067001O75635Q9D695RefSeq mRNA NM 001040147 NM 001261830 NM 001261831 NM 003784NM 027548RefSeq protein NP 001035237 NP 001248759 NP 001248760 NP 003775NP 081824Location UCSC Chr 18 63 75 63 81 MbChr 1 107 33 107 38 MbPubMed searchWikidataView Edit HumanView Edit MouseduephimesxrpinxangxingGRCh38 Ensembl release 89 ENSG00000166396 May 2017 GRCm38 Ensembl release 89 ENSMUSG00000067001 May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene SERPINB7 serpin peptidase inhibitor clade B ovalbumin member 7 aehlngkhxmulxunTsujimoto M Tsuruoka N Ishida N aelakhna 1997 Purification cDNA cloning and characterization of a new serpin with megakaryocyte maturation activity J Biol Chem 272 24 15373 80 doi 10 1074 jbc 272 24 15373 PMID 9182567 Miyata T Nangaku M Suzuki D aelakhna 1998 A mesangium predominant gene megsin is a new serpin upregulated in IgA nephropathy J Clin Invest 102 4 828 36 doi 10 1172 JCI2450 PMC 508946 PMID 9710452 Inagi R Miyata T Suzuki D aelakhna 2001 Specific tissue distribution of megsin a novel serpin in the glomerulus and its up regulation in IgA nephropathy Biochem Biophys Res Commun 286 5 1098 106 doi 10 1006 bbrc 2001 5509 PMID 11527413 Inagi R Miyata T Imasawa T aelakhna 2003 Mesangial cell predominant gene megsin Nephrol Dial Transplant 17 Suppl 9 90009 32 3 doi 10 1093 ndt 17 suppl 9 32 PMID 12386281 Inagi R Miyata T Nangaku M aelakhna 2003 Transcriptional regulation of a mesangium predominant gene megsin PDF J Am Soc Nephrol 13 11 2715 22 doi 10 1097 01 ASN 0000033507 32175 FA PMID 12397041 Strausberg RL Feingold EA Grouse LH aelakhna 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Li YJ Du Y Li CX aelakhna 2004 Family based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3 untranslated region of the Megsin gene J Am Soc Nephrol 15 7 1739 43 doi 10 1097 01 ASN 0000130858 00688 46 PMID 15213261 Suzuki Y Yamashita R Shirota M aelakhna 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions Genome Res 14 9 1711 8 doi 10 1101 gr 2435604 PMC 515316 PMID 15342556 Gerhard DS Wagner L Feingold EA aelakhna 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Inagi R Nangaku M Usuda N aelakhna 2005 Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsin J Am Soc Nephrol 16 5 1339 49 doi 10 1681 ASN 2004070600 PMID 15788472 Xia Y Li Y Du Y aelakhna 2006 Association of MEGSIN 2093C 2180T haplotype at the 3 untranslated region with disease severity and progression of IgA nephropathy Nephrol Dial Transplant 21 6 1570 4 doi 10 1093 ndt gfk096 PMID 16431886 Xia YF Huang S Li X aelakhna 2006 A family based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese population Clin Nephrol 65 3 153 9 doi 10 5414 cnp65153 PMID 16550745 thankhxmulxxniln sahrbeppthieds aelasarybyngeppthieds I04 012 lingkesiy SERPINB7 protein human in sahrbhwkhxenuxhathangkaraephthy MeSH bthkhwamnirwbrwmkhxmulcak sungcdepnsatharnsmbti bthkhwamekiywkhxngkbyinbn niyngepnokhrng khunsamarthchwywikiphiediyidodykarephimetimkhxmul